Enhanced Detection of Vaccine Type Colonization and Dual Serotype Carriage with Molecular Strategies for Identification of Streptococcus pneumoniae Colonization
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منابع مشابه
Evaluation of Prevalence of S. pneumoniae pharyngeal carriers under 5 years of age by lytA gene detection
ABSTRACT Background and Objective: Streptococcus pneumoniae is one of the leading causes of death among children worldwide. Nasopharyngeal colonization in children can spread pneumococcal infections in the community. This study aimed to evaluate the prevalence of S. pneumoniae strains isolated from healthy pharyngeal carriers less than 5 yea...
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Abstract Background and objectives: Colonization of nasopharynx by Streptococcus Pneumoniae can lead to pneumococcal disease. This study was performed to determine the carriage rate of nasopharyngeal S.pneumoniae in adolescents and their antibiotic susceptibility and serotype prevalence in Zahedan, Iran Material and Methods: Nasopharyngeal specimens were obtained from 865 adolescents aged 10-19...
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Background Although asymptomatic carriage of Streptococcus pneumoniae (Spn) is common, acquisition of the bacteria is the first step in disease pathogenesis. We examined the effect of introduction of the 7-valent pneumococcal vaccine on Spn carriage patterns in a cohort of Peruvian children. Methods We used data from a prospective cohort study that collected monthly nasopharyngeal samples fro...
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A murine colonization model was used to determine the effect of co-administering 7-valent polysaccharide-protein conjugate vaccine and pneumococcal surface adhesin A. Mice were challenged intranasally with either PCV7 serotypes, 4 or 14, or a non-PCV7 serotype, 19A. Post-challenge samples were evaluated for IgG antibody levels, opsonophagocytic activity, and nasopharyngeal colonization. No inte...
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Group B Streptococcus (GBS) is a major cause of severe systemic and local infections in newborns. This study was performed to evaluate the presence of GBS in pregnant women and their newborns in Tabriz, Iran. Vaginal specimens were collected from 965 women who were candidate for vaginal delivery for bacteriological study of group B streptococci. Several samples from various sites of the newborn...
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